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Antonio and Augustin Nores-Martinez developed the Dogo Argentino as a large-game hunter in the 1920s. Starting with the now-extinct Fighting Dog of Cordoba, the brothers bred into it the best qualities of the Boxer, Great Dane, Great Pyrenees, Pointer, Irish Wolfhound, Dogue de Bordeaux, Bulldog, Spanish Mastiff and Bull Terrier. The result is an endurance hound of sound mind and body with a stable temperament, able to work in packs. This hard muscled-breed has proven to be highly versatile, valued for its many talents, including schutzhund, police and guide dog work as well as companionship. A Dogo will guard when necessary, but under most circumstances is a friendly, outgoing animal that adores children. An adult male ideally measures no taller than 25 inches at the shoulder; females, slightly smaller. Its short, satiny white coat, which may feature an eye patch or other markings on its head, requires only a once weekly rub with a curry brush. The Dogo is generally a healthy dog, but deafness is known to occur in the breed. This is a loyal dog, but it requires a firm handler and positive training methods. As with any breed, training and socialization should begin as early as 8 weeks of age. The Dogo Argentino was bred to cover long distances quickly with short sprints, so it requires plenty of daily exercise.

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