FDA Approves Drug to Treat Cancer in Dogs

Prescription drug is approved to treat canine cutaneous mast cell tumors.

Posted: June 4, 2009, 5 a.m. EDT

The U.S. Food and Drug Administration has approved Pfizer Animal Health’s Palladia (toceranib phosphate), the first drug developed specifically for the treatment of cancer in dogs. All cancer drugs now used in veterinary medicine originally were developed for use in humans and are not approved for use in animals.

The prescription drug is approved to treat canine cutaneous mast cell tumors, a type of cancer responsible for about 1 out of 5 cases of canine skin tumors, according to the FDA.

The New York-based company said it plans to introduce the product to boarded specialists within the coming weeks and months to expand the body of clinical experience with this new therapy. The drug will be available for purchase in early 2010.

Palladia is an oral therapy indicated to treat Patnaik grade II or III recurrent cutaneous mast cell tumors with or without regional lymph node involvement. The drug belongs to the tyrosine kinase inhibitor class of compounds and works by blocking the activity of key receptors important for the development of blood vessels that supply tumors, as well as receptors critical for tumor survival, according to Pfizer Animal Health.

The most common side effects associated with Palladia are diarrhea, decrease or loss of appetite, lameness, weight loss and blood in stool.


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Kris   Coal valley, Illinois

9/24/2012 8:12:59 PM

My black lab just took his second dose tonight 9/24/12. He takes 95mg every other day. A one month supply is $250.00. There is also weekly lab work and abdominal ultrasounds in addition to cover. I love my dog soooo much. His tumors are in one lung and 2 in the spleen with lymph node involvement that makes it harder to breath and swallow at times. It doesn't help that he inhales his food. He still goes on walks and is a ball fanatic. We are at the point where the cost of treating your dog makes it a real hardship and we're at that point where we really can't afford these bills but what are you suppose to do. How can you say sorry buddy, there are drugs that can help but I can't get them. What do you do when you get here.......... After you've cut back and eliminated so many things already. When you're looking everywhere to cut back and trying to work overtime if theres work. Discontinuing tv services... Using duck tape to help the work bag last longer. Buying something only if its really needed and not just wanted. This is helping us learn how much you have that you don't need. Resets priorities. But then it comes back to my best friend who has cancer and I can't continue to give

you what you need. What do I do then? Maybe the makers of Palladia would want studies on how their med works w mast cell tumors that are not just under the skin but inside organs! Hmmmm

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sal   nh, CT

6/4/2009 10:32:35 PM

wonderful news

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Galadriel   Lothlorien, ME

6/4/2009 8:28:00 PM

This is great. I hope I never have to use it but it's good to know it's around.

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Beverly   Tucson, AZ

6/4/2009 6:47:14 PM

This is wonderful news. I hope the price isn't outrageous.

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