New Lyme Vaccine for Dogs Introduced

Vaccine targets two key outer surface proteins involved in the disease’s transmission.

Posted: June 22, 2009, 5 a.m. EDT

Intervet/Schering-Plough Animal Health recently introduced Nobivac Lyme, a vaccine designed to provide dogs with dual protection against Lyme disease.

The vaccine targets two key outer surface proteins involved in the transmission of canine Lyme disease, according to the Kenilworth, N.J.-based company. It induces the production of highly specific antibodies, called borreliacidal antibodies, which kill Borrelia burgdorferi (the causative agent of Lyme disease) by binding to outer surface proteins (Osp) A and C. Other available products only protect against OspA, according to Rhonda LaFleur, Ph.D., group leader, Biologicals Research and Development at Intervet/Schering-Plough Animal Health.

“This vaccine represents a major advance in the prevention of Lyme disease in dogs because, unlike other Lyme vaccines on the market, it induces OspC borreliacidal antibodies that can kill B. burgdorferi at multiple time points during the infection process,” Dr. LaFleur said. “OspA borreliacidal antibodies only kill Borrelia while they are in the tick midgut. OspC borreliacidal antibodies, however, kill spirochetes in the tick midgut, spirochetes that are migrating from the midgut to the tick’s salivary glands and spirochetes that are introduced into the dog.”

Nobivac Lyme is administered by giving two doses subcutaneously, two to four weeks apart, with an annual booster thereafter. The company reported that safety studies demonstrated virtually no site reactions.

The clinical signs of Lyme disease range from subtle lameness to high fever, swollen lymph nodes, lameness and loss of appetite. Rarely, a dog infected with the disease can develop severe clinical signs that, if left untreated or treated too late, can result in permanent damage to the heart, kidneys, nervous system and joints, or can even be fatal.


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Brandi   Woodstock, Virginia

4/5/2013 5:11:43 AM

Its obvious that all of this stuff is just a very expensive batch of medication that may or may not help. I've been getting all of my dogs vaccinated for lymes, I've been giving them heart guard, and I've been giving them front line, on top of getting them groomed on a very regular basis. To make a long story short, they have to be treated for lymes every few years, because guess what they have!!! This year, they had to be treated for hook worms, even though I treat them for everything...every year its always something, and I spend more than a grand a year on all of this preventative stuff. Well my oldest Siberian Husky who is 13, has arthritis in most of her body, and she has Alzheimer disease. Apparently the Alzheimer disease is a newer thing in dogs, it truly makes me wonder if somehow its not linked to all of these shots and chemicals we are putting into our dogs. I wonder if I had not been giving her the lymes shot if she wouldn't be a healthy happy 13 year old sibe again.

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Pam   Worcester, Massachusetts

2/26/2013 9:21:59 PM

The Lyme Disease Vaccine cannot give your dog Lyme's disease. It is a recombinant vaccine, meaning that it contains no virus, live or dead. It is only about 70% effective at preventing clinical Lyme's Disease, needs to be boosted annualy, and most dogs that get sick even when vaccinated don't seem to get as sick as un-vaccinated dogs. Even if your dog is vaccinated, you should still use a flea and tick preventative like Advantix or Frontline, year round in most of the USA. Ticks carry other diseases that can be deadly. The decision to vaccinate or not in future years if your vaccinated pet tests positive should be made with your veterinarian.

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Jesselena   Mons, Armed Forces

12/7/2012 3:40:32 PM

I am a Canine Massage Therapist, you may want to research Canine Massage Therapy for your dog.

Massage Therapy is designed to enhance and support the general wellness and comfort of your pet. Massages boosts the immune system by increasing the flow of lymphatic fluid and increases circulation of blood through the tissues to foster overall health. In addition, range of movement is improved and muscle function is enhanced.

Although there are numerous conditions that will improve with the aid of massage therapy there are some conditions that can be adversely affected by massage therapy. There is a distinction between knowing when to massage and when not to

The following conditions are contraindications to

Never massage a pet has cancer, circulatory problems, dermatological conditions, acute pain/inflammation, fever, heart conditions, in season, pregnant, post surgery, a fever, or epilepsy.

If your pet is receiving treatment for Lyme Disease, simply keep your dog hydrated and warm with a blanket. Keep their beds off of hard floors (i.e., tile and wood floors), sleeping area should be free from cold drafts. Once the antibiotic(s) treatment is completed, you and your veterinarian can discuss designing a massage therapy program to include stretching exercises and hydrotherapy

I highly recommend using a Certified Canine Therapist to perform massages on your dog. A canine specialist has been trained in clinical anatomy and physiology. Never perform a massage on your pet, unless you have instructed by a professional on how to apply the correct amount of pressure, proper massage strokes, AND special care that is given to all regions of the body. Unfortunately, you can hurt your pet if a massage is not given properly.

* Massage Therapy is an added benefit to your dog's well-care, it does not replace veterinarian care.

I hope this information can help you to help your pet.

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jane   Waverly, Pennsylvania

9/25/2012 3:33:02 AM

My 8 year old dog tested neg for lyme He had minor arthritis and stomach issues if he ate table scraps. Other than that he was completely healthy. The vet gave him the lyme vaccine. Throughout the year he got worse arthritis, tired and his stomach issues got worse, vomiting, diarea, lost weight. Within 14 months he tested positive for lyme and died. I am wondering if the vaccine gave him lyme?? and I wonder what I did wrong. I did not give him monthly Frontline flea and tick because I thought he was covered... If anyone knows if this vaccine can cause lyme in dogs with possible kidney problems please let me know. I have 2 other dogs (completely healthy) and I don't know if I should give them this shot. I have started the Frontline monthly flea/tick treatment though.

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