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Is Elevated Liver Count in Dog Bad News?

A dog with an elevated liver count may be just fine.

By Jon Geller, DVM

Q. I just took my 7-year-old West Highland White Terrier to the vet. Her blood work revealed that her “liver count was up.” She is going to have follow-up blood tests soon. What do think they are looking for?

A. The results of routine lab tests can sometimes come back as abnormal, and this can wreak emotional havoc on dog owners and human patients alike.
 
Although early detection of disease is important to successful treatment, there are often circumstances where one or more of the values are up for no apparent reasons. The result can be expensive follow-up tests, anxiety, and possibly unnecessary treatments that carry significant side effects.
 
If your dog has routine screening tests, it is important to match up any clinical signs, or symptoms, with abnormal test results to help determine if the out-of-range result is significant and warrants follow-up.
 
In the case of liver tests, it is not unusual for one or two of the liver enzymes to be mildly to moderately elevate in a middle-aged dog. However, if there were to be signs such as vomiting, diarrhea, lethargy, fever, loss of appetite or other changes that went along with the abnormal results, there would be more urgency.
 
Tests such as liver biopsies and ultrasounds can end up being costly wild goose chases for dog owners if there are no clinical signs to confirm possible liver disease.
 
I would discuss the need for further testing with your veterinarian, specifically asking what diseases are being considered. If your dog has been acting normal, it would not be unreasonable to suggest re-testing in another year, or sooner if anything changes.
 
One exception to this suggestion is in geriatric dogs (more than 10 years old). It is important to closely follow any abnormal blood values, and twice-a-year routine testing is recommended.

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Reader Comments
Two years ago, a routine blood test revealed elevated liver enzymes for my 6 year old Coton De Tulear. The Dr checked the enzymes again the following month and it increased to nearly 200. At that point, I was referred to a specialist and within two months my dog's liver enzymes had climbed to nearly 800. The only change in his behavior was that he was sleeping more. Thankfully, I had pet insurance so we did an ultrasound, and when that provided no definitive answers we had a biopsy. The biopsy showed my dog had copper storage syndrome and a congenital liver disease. The Dr started my dog on Marin, Sam-E, fish oil, and vegan dog food. I also had my water tested (we have well water) and learned the copper was 1/10 above safe limits for humans so needless to say my dog and my family have been drinking bottled water ever since. After three months of this regimen, my dog's liver enzymes decreased to 155 and have remained between 151-155 for the past two years. What a blessing! The dr said because we caught it early and are treating it, he should live a long and healthy life. I realize every story is different but I am sharing mine because there is a small chance it may help others.
Jackie, Manchester, NH
Posted: 1/8/2012 3:14:18 PM
My 14.5 year old Border Collie X in very good health and spirits (except for periodic IBD occurances) just started vomiting brownish bile and was generally lethargic... wouldn't eat or get up. Blood test shows liver level of 3000. Her vet suggests an ultrasound or biopsy or, as a less invasive option, antibiotics for a week just in case the elevation is due to a virus of some sort. Not sure what to do... don't want her to be suffering for a week if there is a tumor or some other issue. If it is a tumor, it is unlikely we will operate because of her advanced age. What is liklihood that the antibiotics will "cure" what is wrong with her?
Eileen, Phoenix, AZ
Posted: 11/22/2011 10:28:28 AM
Hi my dog Ethel is a shitzu and she is 11 years old. A few months ago her liver enzymes were elevated in the 900 range and she was put on some meds. Last week we redid her blood work and they increased to 2700. She is acting normal with no symptoms. The only thing I have noticed is she is drinking an excessive amount of water other than that nothing else. My vet wants to do an nultrasound which is very costly. I am not sure what to do, any suggestions?
Vania, Miami, FL
Posted: 11/5/2011 8:26:40 AM
I would like to agree with Dr. Geller. My dog has recently gone through a routine blood test and it was discovered that his lever ensymes were elevated. 2 weeks later he was retested and the same liver ensymes went down and were half as elevated. The vet naturally wants to do an ultrasound. The dog is a 2 1/2 year old Havanese and is taking Denosyl and Milk Thisle for 3 weeks. I would like to retest again for a 3rd time in a few weeks before doing an ultrasound. He was originally prescribed Clavamox, Bayril, Densoyl and milk thistle after the first blood test.
Barbara, Brooklyn, NY
Posted: 10/29/2011 3:02:02 PM
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